Identification of human-derived volatile chemicals that interfere with attraction of Aedes aegypti mosquitoes.


Logan, JG; Birkett, MA; Clark, SJ; Powers, S; Seal, NJ; Wadhams, LJ; Mordue Luntz, AJ; Pickett, JA; (2008) Identification of human-derived volatile chemicals that interfere with attraction of Aedes aegypti mosquitoes. Journal of chemical ecology, 34 (3). pp. 308-22. ISSN 0098-0331 DOI: https://doi.org/10.1007/s10886-008-9436-0

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Abstract

It is known that human individuals show different levels of attractiveness to mosquitoes. In this study, we investigated the chemical basis for low attractiveness. We recorded behaviors of Aedes aegypti toward the hands of human volunteers and toward the volatile chemicals produced by their bodies. Some individuals, and their corresponding volatiles, elicited low upwind flight, relative attraction, and probing activity. Analyzing the components by gas chromatography coupled to electrophysiological recordings from the antennae of Aedes aegypti, enabled the location of 33 physiologically relevant compounds. The results indicated that higher levels of specific compounds may be responsible for decreased "attractiveness." In behavioral experiments, five of the compounds caused a significant reduction in upwind flight of Aedes aegypti to attractive human hands. Thus, unattractiveness of individuals may result from a repellent, or attractant "masking," mechanism.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
PubMed ID: 18306972
Web of Science ID: 253975100004
URI: http://researchonline.lshtm.ac.uk/id/eprint/1747

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