Environmental risk factors in congenital malformations of the eye

Hornby, SJ; Ward, SJ; Gilbert, CE; Dandona, L; Foster, A; Jones, RB; (2002) Environmental risk factors in congenital malformations of the eye. Annals of tropical paediatrics, 22 (1). pp. 67-77. ISSN 0272-4936 DOI: https://doi.org/10.1179/027249302125000193

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Developmental eye defects such as coloboma are a significant cause of visual morbidity in children, and are more common in India than elsewhere. The possible role of environmental factors in the aetiology of these conditions was investigated by studying birth order, symptoms of vitamin A deficiency (night blindness), drug use and maternal illness in pregnancy, rubella antibodies and exposure to agricultural chemicals. Through hospital records and community-based rehabilitation programmes in Andhra Pradesh, children with colobomata were recruited from schools for the blind. Eighty-three mothers of affected children were interviewed. The results showed that 43% of parents were consanguineous, that 19% had a positive family history and that the frequency of coloboma was highest in second-born children. Eleven (16%) mothers had a history of night blindness while pregnant with the affected child; seven (8%) took medication during the 1st trimester, abortifacients in two cases; three reported fever in the 1st trimester; and 11 (13%) reported exposure to agricultural chemicals.

Item Type: Article
Keywords: Consecutive births, head defects, microphthalmos, coloboma, rat, anophthalmia, hyperthermia, diagnosis, exposure, benomyl, Abnormalities, Multiple, embryology, genetics, Adolescent, Adult, Agrochemicals, adverse effects, Birth Order, Child, Child, Preschool, Coloboma, embryology, genetics, Consanguinity, Environmental Exposure, Eye Abnormalities, embryology, genetics, Female, Human, Infant, Infant, Newborn, Male, Microphthalmos, embryology, genetics, Middle Age, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Support, Non-U.S. Gov't, Vitamin A Deficiency, complications
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: The International Centre for Evidence in Disability
International Centre for Eye Health
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 11926054
Web of Science ID: 174564300011
URI: http://researchonline.lshtm.ac.uk/id/eprint/17366


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