Genetics and the common cancers


Peto, J; Houlston, RS; (2001) Genetics and the common cancers. European journal of cancer (Oxford, England, 37 Suppl 8. S88-96. ISSN 0959-8049

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Abstract

Rare highly penetrant genes cannot account for much of the familial risk for most common cancers, and there is increasing evidence that a high proportion of cancers arise in a susceptible minority who carry low-penetrance genes or gene combinations. The evidence for the existence of such genes and the prospects for identifying them are reviewed.

Item Type: Article
Keywords: cancer genetics, low-penetration genes, linkage analysis, segregation analysis, review, S-transferase m1, breast-cancer, bladder-cancer, lung-cancer, susceptibility gene, colorectal cancers, risk, locus, melanoma, linkage, Female, Genetic Predisposition to Disease, Human, Linkage (Genetics), Male, Neoplasms, genetics, Neoplastic Syndromes, Hereditary, genetics, Penetrance
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 11602375
Web of Science ID: 172126400005
URI: http://researchonline.lshtm.ac.uk/id/eprint/17330

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