Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan.

Leslie, T; Whitehouse, CA; Yingst, S; Baldwin, C; Kakar, F; Mofleh, J; Hami, AS; Mustafa, L; Omar, F; Ayazi, E; Rossi, C; Noormal, B; Ziar, N; Kakar, R; (2011) Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan. Epidemiology and infection, 139 (5). pp. 728-35. ISSN 0950-2688 DOI: https://doi.org/10.1017/S0950268810001792

Text - Published Version
License: Copyright the publishers

Download (148kB) | Preview


: Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment. In late December 2007, an outbreak of acute gastroenteritis occurred in Nimroz Province of southern Afghanistan. Of the 83 probable cases of illness, 17 died (case fatality 20·5%). Being a case was associated with consumption or handling of camel meat (adjusted odds ratio 4·4, 95% confidence interval 2·2-8·8, P<0·001). Molecular testing of patient clinical samples and of tissue from the camel using PCR/electrospray ionization-mass spectrometry revealed DNA signatures consistent with Yersinia pestis. Confirmatory testing using real-time PCR and immunological seroconversion of one of the patients confirmed that the outbreak was caused by plague, with a rare gastrointestinal presentation. The study highlights the challenges of identifying infectious agents in low-resource settings; it is the first reported occurrence of plague in Afghanistan.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
PubMed ID: 20663260
Web of Science ID: 290105400010
URI: http://researchonline.lshtm.ac.uk/id/eprint/1733


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item