Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia


Aucan, C; Walley, AJ; Greenwood, BM; Hill, AVS; (2002) Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 (3). pp. 327-8. ISSN 0035-9203 DOI: 10.1016/S0035-9203(02)90114-8

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Abstract

The influence of haptoglobin polymorphisms on severe malaria occurrence was assessed in 1183 individuals from The Gambia. No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribonucleic acid-based haptoglobin typing method are discussed.

Item Type: Article
Keywords: malaria, Plasmodium falciparum, haptoglobin, gene, polymorphisms, pathogenesis, The Gambia, Falciparum-malaria, polymorphism, mortality, africa, Case-Control Studies, Gambia, Gene Frequency, Genetic Predisposition to Disease, Genotype, Haptoglobins, genetics, Human, Immunity, Natural, genetics, Malaria, Falciparum, genetics, immunology, Polymorphism (Genetics), Support, Non-U.S. Gov't
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 12174790
Web of Science ID: 177161900024
URI: http://researchonline.lshtm.ac.uk/id/eprint/17213

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