Coffee consumption and serum aminotransferases in middle-aged Japanese men


Honjo, S; Kono, S; Coleman, MP; Shinchi, K; Sakurai, Y; Todoroki, I; Umeda, T; Wakabayashi, K; Imanishi, K; Nishikawa, H; Ogawa, S; Katsurada, M; Nakagawa, K; Yoshizawa, N; (2001) Coffee consumption and serum aminotransferases in middle-aged Japanese men. Journal of clinical epidemiology, 54 (8). pp. 823-9. ISSN 0895-4356

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Abstract

We investigated the relation between coffee drinking and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations among 7313 Japanese men receiving a health examination, excluding former alcohol drinkers and men with a history of chronic liver disease. Serum AST > 40 and/or ALT > 40 U/L was defined as liver inflammation. Adjustment was made for alcohol use, smoking, body mass index, serum marker for hepatitis virus infection, and other possible confounders. Adjusted odds ratios of liver inflammation were 1.00 (reference), 0.80, 0.69, and 0.61 for men drinking < 1, 1-2, 3-4, and > or = 5 cups of coffee daily, respectively. Among 6898 men without liver inflammation, serum AST and ALT were inversely associated with coffee consumption, and alcohol-related rise in AST was attenuated with coffee drinking. These findings suggest coffee may have an effect of suppressing the rise of serum aminotransferase, partly by inhibiting the alcohol-related elevation. Studies regarding biological mechanism are warranted.

Item Type: Article
Keywords: alcohol, epidemiology, filtered coffee, instant coffee, obesity, viral hepatitis, Gamma-glutamyl-transferase, self-defense officials, population, determinants, liver aminotransferases, sigmoid colon, alcohol, lipids, enzymes, smoking, cirrhosis, Alanine Transaminase, blood, Alcohol Drinking, Aspartate Aminotransferases, blood, Body Mass Index, Coffee, therapeutic use, Cross-Sectional Studies, Human, Inflammation, prevention & control, Japan, epidemiology, Liver Diseases, epidemiology, prevention & control, Male, Middle Age, Phytotherapy, Questionnaires, Regression Analysis, Support, Non-U.S. Gov't
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Cancer Survival Group
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 11470392
Web of Science ID: 170019900010
URI: http://researchonline.lshtm.ac.uk/id/eprint/17133

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