Survival from acute non-lymphocytic leukaemia (ANLL) and chronic myeloid leukaemia (CML) in European children since 1978: a population-based study

Gatta, G; Luksch, R; Coleman, MP; Corazziari, I; (2001) Survival from acute non-lymphocytic leukaemia (ANLL) and chronic myeloid leukaemia (CML) in European children since 1978: a population-based study. European journal of cancer (Oxford, England, 37 (6). pp. 695-702. ISSN 0959-8049

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We used data supplied by population-based cancer registries, collected and quality controlled using a common protocol, to analyse survival from acute non-lymphocytic leukaemia (ANLL) and chronic myeloid leukaemia (CML) among children in 17 European countries. Variations in survival in relation to age, country, histologic subtype and period of diagnosis (1978--1992) were examined. These are rare malignancies and survival can be studied reliably only by examination of data from a very large population (in this case EUROCARE). 5 years after diagnosis, overall survival was 44% (95% CI 33--55) for CML and 37% (95% CI 32--43) for ANLL. For both types of leukaemia, survival was slightly better for girls and worse in children under 5 years of age. Consistent with clinical literature, the ANLL subtypes with poorer prognosis were monocytic, megakaryocytic and erythroleukaemia. For ANLL, 5-year survival was better in Finland, the UK, The Netherlands and Germany (> or =40%); for CML, 5-year survival was highest in Italy, although the 95% CI were wide. The risk of death from ANLL and CML fell by 7% per year and 5% per year, respectively, after adjustment for age, gender and country. Since these rare childhood malignancies were virtually untreatable until 1970, these are very welcome trends.

Item Type: Article
Keywords: childhood cancer, population-based cancer registries, survival, survival trends, gender contrast, chronic myeloid leukaemia, acute non-lymphocytic leukaemia, Europe, Childhood-cancer, diagnosis, Adolescence, Age Distribution, Child, Child, Preschool, Europe, epidemiology, Female, Follow-Up Studies, Human, Infant, Infant, Newborn, Leukemia, Lymphocytic, Acute, mortality, Leukemia, Myeloid, Chronic, mortality, Male, Prognosis, Registries, Residence Characteristics, Sex Distribution, Support, Non-U.S. Gov't, Survival Rate, trends, Time Factors
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Cancer Survival Group
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 11311643
Web of Science ID: 168366400005


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