Prospective study of measles in hospitalized, human immunodeficiency virus (HIV)-infected and HIV-uninfected children in Zambia


Moss, WJ; Monze, M; Ryon, JJ; Quinn, TC; Griffin, DE; Cutts, F; (2002) Prospective study of measles in hospitalized, human immunodeficiency virus (HIV)-infected and HIV-uninfected children in Zambia. Clinical infectious diseases , 35 (2). pp. 189-96. ISSN 1058-4838 DOI: 10.1086/341248

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Abstract

Measles in persons coinfected with human immunodeficiency virus (HIV) has been reported to be unusual in its presentation and frequently fatal. To determine the effect of HIV coinfection on the clinical features and outcome of measles, a prospective study of hospitalized children with measles was conducted between January 1998 and October 2000 in Lusaka, Zambia. One-sixth (17%) of 546 children hospitalized with laboratory-confirmed measles were coinfected with HIV. One-third of the HIV-infected children hospitalized with confirmed measles were <9 months old, compared with 23% of HIV-uninfected children (P=.03). Few differences in clinical manifestations, complications, or mortality were found between HIV-infected and HIV-uninfected children with measles. HIV-infected children constitute a significant proportion of children hospitalized with measles in countries with high HIV prevalence and are more likely to be younger than the age for routine measles immunization.

Item Type: Article
Keywords: Infected children, immunity, vaccination, AIDS-Related Opportunistic Infections, diagnosis, epidemiology, immunology, prevention & control, CD4-Positive T-Lymphocytes, pathology, Child, Hospitalized, Child, Preschool, Female, HIV Infections, epidemiology, immunology, HIV Seronegativity, immunology, HIV Seropositivity, diagnosis, epidemiology, immunology, Human, Immunization Programs, Infant, Lymphocyte Count, Male, Measles, diagnosis, epidemiology, immunology, prevention & control, Measles Vaccine, therapeutic use, Measles virus, immunology, Prospective Studies, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., T-Lymphocyte Subsets, pathology, Zambia, epidemiology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 12087526
Web of Science ID: 176475100011
URI: http://researchonline.lshtm.ac.uk/id/eprint/16914

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