Suppression of human immunodeficiency virus replication during acute measles


Moss, WJ; Ryon, JJ; Monze, M; Cutts, F; Quinn, TC; Griffin, DE; (2002) Suppression of human immunodeficiency virus replication during acute measles. The Journal of infectious diseases, 185 (8). pp. 1035-42. ISSN 0022-1899 DOI: 10.1086/340027

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Abstract

To determine the effect of measles virus coinfection on plasma human immunodeficiency virus (HIV) RNA levels, a prospective study of hospitalized children with measles was conducted between January 1998 and October 2000 in Lusaka, Zambia. Plasma HIV RNA levels were measured during acute measles and 1 month after hospital discharge. The median plasma HIV RNA level in 33 children with measles who were followed longitudinally was 5339 copies/mL at study entry, 60,121 copies/mL at hospital discharge, and 387,148 copies/mL at 1-month follow-up. The median plasma HIV RNA level in children without acute illness was 228,454 copies/mL. Plasma levels of immune activation markers were elevated during the period of reduced plasma HIV RNA. Plasma levels of several potential HIV suppressive factors also were elevated during acute measles. HIV replication is transiently suppressed during acute measles at a time of intense immune activation.

Item Type: Article
Keywords: Hiv-infected infants, t-cell activation, immune activation, disease progression, type-1 replication, viral replication, serum levels, prognostic-significance, uncomplicated disease, influenza vaccination, Acute Disease, Antigens, CD, blood, CD4 Lymphocyte Count, Child, Preschool, Female, HIV, physiology, Human, Infant, Macrophage Inflammatory Protein-1, blood, Male, Measles, immunology, virology, RANTES, blood, RNA, Viral, blood, Receptors, Interleukin-2, analysis, Receptors, Tumor Necrosis Factor, blood, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., Virus Replication
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 11930312
Web of Science ID: 174726800006
URI: http://researchonline.lshtm.ac.uk/id/eprint/16913

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