Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial.


Webb, EL; Mawa, PA; Ndibazza, J; Kizito, D; Namatovu, A; Kyosiimire-Lugemwa, J; Nanteza, B; Nampijja, M; Muhangi, L; Woodburn, PW; Akurut, H; Mpairwe, H; Akello, M; Lyadda, N; Bukusuba, J; Kihembo, M; Kizza, M; Kizindo, R; Nabulime, J; Ameke, C; Namujju, PB; Tweyongyere, R; Muwanga, M; Whitworth, JA; Elliott, AM; (2011) Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial. Lancet, 377 (9759). pp. 52-62. ISSN 0140-6736 DOI: https://doi.org/10.1016/S0140-6736(10)61457-2

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Abstract

Helminth infections affect the human immune response. We investigated whether prenatal exposure to and treatment of maternal helminth infections affects development of an infant's immune response to immunisations and unrelated infections.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Neglected Tropical Diseases Network
Tropical Epidemiology Group
PubMed ID: 21176950
Web of Science ID: 286445200031
URI: http://researchonline.lshtm.ac.uk/id/eprint/1680

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