Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers


Dumpis, U; Mendy, M; Hill, A; Thursz, M; Hall, A; Whittle, H; Karayiannis, P; (2001) Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers. Journal of medical virology, 65 (4). pp. 664-70. ISSN 0146-6615

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Abstract

One hundred forty-two precore/core sequences were obtained from Gambian chronic hepatitis B virus (HBV) carriers and the predominant variants defined. The two point mutations, from A to T and G to A at nt positions 1762 and 1764 in the basic core promoter region, were found in only 7/99 (7%) of the samples where this region was sequenced. These mutations were found in both HBeAg-positive and -negative patients. The precore stop-codon mutation at nt position 1896 was found in 14/51 (27%) of HBeAg-negative samples, which is a lower prevalence rate in comparison with other parts of the world with high carrier rates. In HBeAg-positive patients the core amino acid sequences were conserved, but after seroconversion to anti-HBe significantly more changes were apparent. Several of the amino acid substitutions found have been described previously been in wild-type viruses of other genotypes.

Item Type: Article
Keywords: hepatitis B virus, genotype, genomic mutations, basic core, promoter, precore/core, Hepatitis-b-virus, surface-antigen, nucleotide-sequence, infection, fulminant, gene, relatedness, genotypes, variants, strains, Amino Acid Sequence, Amino Acid Substitution, Carrier State, epidemiology, virology, Cloning, Molecular, Codon, Terminator, Gambia, epidemiology, Genes, Viral, Hepatitis B Virus, genetics, Hepatitis B e Antigens, analysis, Hepatitis B, Chronic, epidemiology, immunology, virology, Human, Molecular Sequence Data, Mutation, Promoter Regions (Genetics), Viral Core Proteins, genetics
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 11745929
Web of Science ID: 171993900006
URI: http://researchonline.lshtm.ac.uk/id/eprint/16761

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