Maternal nutrition at conception modulates DNA methylation of human metastable epialleles


Dominguez-Salas, P; Moore, SE; Baker, MS; Bergen, AW; Cox, SE; Dyer, RA; Fulford, AJ; Guan, Y; Laritsky, E; Silver, MJ; Swan, GE; Zeisel, SH; Innis, SM; Waterland, RA; Prentice, AM; Hennig, BJ; (2014) Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications, 5. ISSN 2041-1723 DOI: 10.1038/ncomms4746

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Abstract

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Funders: Wellcome Trust, UK Medical Research Council (MRC), UK Department for the International Development (DFID) under the MRC/DFID Concordat agreement, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, USDA, SRI’s Center for Health Sciences
Grant number: WT086369MA, MC-A760-5QX00, 1R01DK081557, CRIS 6250-51000-055, DA011170, DA020830
PubMed ID: 24781383
URI: http://researchonline.lshtm.ac.uk/id/eprint/1673645

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