The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer.

Shan, L; Ambroisine, L; Clark, J; Yáñez-Muñoz, RJ; Fisher, G; Kudahetti, SC; Yang, J; Kia, S; Mao, X; Fletcher, A; Flohr, P; Edwards, S; Attard, G; De-Bono, J; Young, BD; Foster, CS; Reuter, V; Moller, H; Oliver, TD; Berney, DM; Scardino, P; Cuzick, J; Cooper, CS; Lu, YJ; Transatlantic Prostate Group, ; (2010) The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer. Prostate cancer and prostatic diseases, 13 (2). pp. 117-25. ISSN 1365-7852 DOI:

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Our previous work identified a chromosomal translocation t(4;6) in prostate cancer cell lines and primary tumors. Using probes located on 4q22 and 6q15, the breakpoints identified in LNCaP cells, we performed fluorescence in situ hybridization analysis to detect this translocation in a large series of clinical localized prostate cancer samples treated conservatively. We found that t(4;6)(q22;q15) occurred in 78 of 667 cases (11.7%). The t(4;6)(q22;q15) was not independently associated with patient outcome. However, it occurs more frequently in high clinical T stage, high tumor volume specimens and in those with high baseline PSA (P=0.001, 0.001 and 0.01, respectively). The t(4;6)(q22;q15) occurred more frequently in samples with two or more TMPRSS2:ERG fusion genes caused by internal deletion than in samples without these genomic alterations, but this correlation is not statistically significant (P=0.0628). The potential role of this translocation in the development of human prostate cancer is discussed.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 20177423
Web of Science ID: 277626300003


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