Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer.


Reid, AH; Attard, G; Ambroisine, L; Fisher, G; Kovacs, G; Brewer, D; Clark, J; Flohr, P; Edwards, S; Berney, DM; Foster, CS; Fletcher, A; Gerald, WL; Møller, H; Reuter, VE; Scardino, PT; Cuzick, J; de Bono, JS; Cooper, CS; Transatlantic Prostate Group, ; (2010) Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. British journal of cancer, 102 (4). pp. 678-84. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6605554

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Abstract

The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 20104229
Web of Science ID: 274604900008
URI: http://researchonline.lshtm.ac.uk/id/eprint/1669

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