RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID-TIA): study protocol for a pilot randomised controlled trial

Edwards, D; Fletcher, K; Deller, R; McManus, R; Lasserson, D; Giles, M; Sims, D; Norrie, J; McGuire, G; Cohn, S; Whittle, F; Hobbs, V; Weir, C; Mant, J; (2013) RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID-TIA): study protocol for a pilot randomised controlled trial. Trials, 14. p. 194. ISSN 1745-6215 DOI: https://doi.org/10.1186/1745-6215-14-194

Text - Published Version

Download (469kB) | Preview


People who have a transient ischaemic attack (TIA) or minor stroke are at high risk of a recurrent stroke, particularly in the first week after the event. Early initiation of secondary prevention drugs is associated with an 80% reduction in risk of stroke recurrence. This raises the question as to whether these drugs should be given before being seen by a specialist - that is, in primary care or in the emergency department. The aims of the RAPID-TIA pilot trial are to determine the feasibility of a randomised controlled trial, to analyse cost effectiveness and to ask: Should general practitioners and emergency doctors (primary care physicians) initiate secondary preventative measures in addition to aspirin in people they see with suspected TIA or minor stroke at the time of referral to a specialist?

Item Type: Article
Keywords: Antihypertensive Agents, administration & dosage, Aspirin, administration & dosage, Cardiovascular Agents, administration & dosage, adverse effects, Clinical Protocols, Dipyridamole, administration & dosage, Drug Administration Schedule, Drug Therapy, Combination, Emergency Service, Hospital, England, Feasibility Studies, General Practice, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, administration & dosage, Ischemic Attack, Transient, diagnosis, drug therapy, Pilot Projects, Primary Health Care, Recurrence, prevention & control, Referral and Consultation, Research Design, Secondary Prevention, methods, Simvastatin, administration & dosage, Time Factors, Treatment Outcome
Faculty and Department: Faculty of Public Health and Policy > Dept of Health Services Research and Policy
PubMed ID: 23819476
Web of Science ID: 321926800001
URI: http://researchonline.lshtm.ac.uk/id/eprint/1665727


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item