Antiprotozoal activities of phospholipid analogues


Croft, SL; Seifert, K; Duchene, M; (2003) Antiprotozoal activities of phospholipid analogues. Molecular and biochemical parasitology, 126 (2). pp. 165-72. ISSN 0166-6851 DOI: 10.1016/S0166-6851(02)00283-9

Full text not available from this repository. (Request a copy)

Abstract

The antiprotozoal activity of phospholipid analogues, originally developed as anti-cancer drugs, has been determined in the past decade. The most susceptible parasites are Leishmania spp. and Trypanosoma cruzi with activity also shown against Trypanosoma brucei spp., Entamoeba histolytica and Acanthamoeba spp. Miltefosine, an alkylphosphocholine, was registered for the oral treatment of visceral leishmaniasis (VL) in India in March 2002. This review will focus on the biological activities of phospholipid analogues. Biochemical and molecular targets and mechanism(s) of action have been studied extensively in tumor cells but have not been determined in protozoa.

Item Type: Article
Keywords: Animal, Antiprotozoal Agents/chemistry/*pharmacology/therapeutic use, Leishmania/drug effects, Parasitic Sensitivity Tests, Phospholipid Ethers/chemistry/pharmacology, Phospholipids/chemistry/*pharmacology/therapeutic use, Phosphorylcholine/*analogs & derivatives/chemistry/pharmacology, Structure-Activity Relationship, Support, Non-U.S. Gov't, Trypanosoma/drug effects, Animal, Antiprotozoal Agents, chemistry, pharmacology, therapeutic use, Leishmania, drug effects, Parasitic Sensitivity Tests, Phospholipid Ethers, chemistry, pharmacology, Phospholipids, chemistry, pharmacology, therapeutic use, Phosphorylcholine, analogs & derivatives, chemistry, pharmacology, Structure-Activity Relationship, Support, Non-U.S. Gov't, Trypanosoma, drug effects
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Antimicrobial Resistance Centre (AMR)
Leishmaniasis Group
PubMed ID: 12615315
Web of Science ID: 181760700005
URI: http://researchonline.lshtm.ac.uk/id/eprint/16585

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
340Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item