Antiprotozoal activities of phospholipid analogues

Croft, SL; Seifert, K; Duchene, M; (2003) Antiprotozoal activities of phospholipid analogues. Molecular and biochemical parasitology, 126 (2). pp. 165-72. ISSN 0166-6851 DOI:

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The antiprotozoal activity of phospholipid analogues, originally developed as anti-cancer drugs, has been determined in the past decade. The most susceptible parasites are Leishmania spp. and Trypanosoma cruzi with activity also shown against Trypanosoma brucei spp., Entamoeba histolytica and Acanthamoeba spp. Miltefosine, an alkylphosphocholine, was registered for the oral treatment of visceral leishmaniasis (VL) in India in March 2002. This review will focus on the biological activities of phospholipid analogues. Biochemical and molecular targets and mechanism(s) of action have been studied extensively in tumor cells but have not been determined in protozoa.

Item Type: Article
Keywords: Animal, Antiprotozoal Agents/chemistry/*pharmacology/therapeutic use, Leishmania/drug effects, Parasitic Sensitivity Tests, Phospholipid Ethers/chemistry/pharmacology, Phospholipids/chemistry/*pharmacology/therapeutic use, Phosphorylcholine/*analogs & derivatives/chemistry/pharmacology, Structure-Activity Relationship, Support, Non-U.S. Gov't, Trypanosoma/drug effects, Animal, Antiprotozoal Agents, chemistry, pharmacology, therapeutic use, Leishmania, drug effects, Parasitic Sensitivity Tests, Phospholipid Ethers, chemistry, pharmacology, Phospholipids, chemistry, pharmacology, therapeutic use, Phosphorylcholine, analogs & derivatives, chemistry, pharmacology, Structure-Activity Relationship, Support, Non-U.S. Gov't, Trypanosoma, drug effects
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Antimicrobial Resistance Centre (AMR)
Leishmaniasis Group
PubMed ID: 12615315
Web of Science ID: 181760700005


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