Drug sensitivity of Leishmania species: some unresolved problems


Croft, SL; Yardley, V; Kendrick, H; (2002) Drug sensitivity of Leishmania species: some unresolved problems. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 Suppl 1. S127-9. ISSN 0035-9203

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Abstract

Leishmania species show a significant variation in their sensitivity to established and experimental drugs. Molecular techniques to identify species in clinical infections rapidly could be used to guide treatment. Molecular markers are required to detect and monitor acquired resistance to antimonial drugs. Reporter genes and the polymerase chain reaction will improve assays both in vitro and in vivo for the identification and evaluation of new drugs.

Item Type: Article
Keywords: Animal, Antiprotozoal Agents/*pharmacology, Drug Evaluation, Preclinical/methods, Drug Resistance, Human, Leishmania/classification/*drug effects, Parasitic Sensitivity Tests, Support, Non-U.S. Gov't, Animal, Antiprotozoal Agents, pharmacology, Drug Evaluation, Preclinical, methods, Drug Resistance, Human, Leishmania, classification, drug effects, Parasitic Sensitivity Tests, Support, Non-U.S. Gov't
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
Neglected Tropical Diseases Network
PubMed ID: 12055825
URI: http://researchonline.lshtm.ac.uk/id/eprint/16578

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