Monitoring drug resistance in leishmaniasis


Croft, SL; (2001) Monitoring drug resistance in leishmaniasis. Tropical medicine & international health , 6 (11). pp. 899-905. ISSN 1360-2276

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Abstract

There are many factors that can influence the efficacy of drugs in the treatment of leishmaniasis. These include both an intrinsic variation in the sensitivity of Leishmania species, described for pentavalent antimonials, paromomycin, azoles and other drugs that have reached clinical trials, as well as acquired drug resistance to antimonials. Acquired resistance has been studied in the laboratory for several decades but it is only recently that clinical resistance in L. donovani field isolates has been demonstrated. The monitoring of resistance is problematic due to a reliance on the amastigote-macrophage culture assay to adequately correlate clinical and in vitro resistance and a lack of knowledge about the molecular and biochemical mechanisms of resistance to antileishmanial drugs.

Item Type: Article
Keywords: Animal, Antiprotozoal Agents/pharmacokinetics/*therapeutic use, Dose-Response Relationship, Drug, *Drug Resistance, Human, Immunocompetence, Leishmania/drug effects/genetics/isolation & purification, Leishmaniasis/*drug therapy/immunology/parasitology, Parasitic Sensitivity Tests/methods/standards, Species Specificity, Variation (Genetics), Animal, Antiprotozoal Agents, pharmacokinetics, therapeutic use, Dose-Response Relationship, Drug, Drug Resistance, Human, Immunocompetence, Leishmania, drug effects, genetics, isolation & purification, Leishmaniasis, drug therapy, immunology, parasitology, Parasitic Sensitivity Tests, methods, standards, Species Specificity, Variation (Genetics)
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Antimicrobial Resistance Centre (AMR)
Leishmaniasis Group
Neglected Tropical Diseases Network
PubMed ID: 11703844
Web of Science ID: 172100000009
URI: http://researchonline.lshtm.ac.uk/id/eprint/16571

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