Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa


Jepson, A; Fowler, A; Banya, W; Singh, M; Bennett, S; Whittle, H; Hill, AVS; (2001) Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa. Infection and immunity, 69 (6). pp. 3989-3994. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.69.6.3989-3994.2001

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Abstract

The role of genetic factors in clinical tuberculosis is increasingly recognized; how such factors regulate the immune response to Mycobacterium tuberculosis in healthy individuals is unclear. In this study of 255 adult twin pairs residing in The Gambia, West Africa, it is apparent that memory T-cell responses to secreted mycobacterial antigens (85-kDa antigen complex, "short-term culture filtrate," and peptides from the ESAT-6 protein), as well as to the 65-kDa heat shock protein, are subject to effective genetic regulation. The delayed hypersensitivity response to intradermal tuberculin also demonstrates significant genetic variance, while quantitative T-cell and antibody responses to the 38-kDa cell membrane protein appear to be determined largely by environmental factors. Such findings have implications for vaccine development.

Item Type: Article
Keywords: T-cell responses, healthy household contacts, bacillus-, calmette-guerin, bcg immunization, esat-6 antigen, receptor, gene, protein, reactivity, infection, vaccination, Adolescence, Antigens, Bacterial, immunology, Child, Diseases in Twins, Female, Gambia, Genetic Predisposition to Disease, Human, Interferon Type II, metabolism, Lymphocyte Transformation, immunology, Male, Mycobacterium tuberculosis, immunology, Skin Tests, Support, Non-U.S. Gov't, T-Lymphocytes, immunology, Tuberculosis, genetics, immunology, Twins
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 11349068
Web of Science ID: 168784300060
URI: http://researchonline.lshtm.ac.uk/id/eprint/16557

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