Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa
Jepson, A; Fowler, A; Banya, W; Singh, M; Bennett, S; Whittle, H; Hill, AVS; (2001) Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa. Infection and immunity, 69 (6). pp. 3989-3994. ISSN 0019-9567 DOI: 10.1128/IAI.69.6.3989-3994.2001Full text not available from this repository.
The role of genetic factors in clinical tuberculosis is increasingly recognized; how such factors regulate the immune response to Mycobacterium tuberculosis in healthy individuals is unclear. In this study of 255 adult twin pairs residing in The Gambia, West Africa, it is apparent that memory T-cell responses to secreted mycobacterial antigens (85-kDa antigen complex, "short-term culture filtrate," and peptides from the ESAT-6 protein), as well as to the 65-kDa heat shock protein, are subject to effective genetic regulation. The delayed hypersensitivity response to intradermal tuberculin also demonstrates significant genetic variance, while quantitative T-cell and antibody responses to the 38-kDa cell membrane protein appear to be determined largely by environmental factors. Such findings have implications for vaccine development.
|Keywords:||T-cell responses, healthy household contacts, bacillus-, calmette-guerin, bcg immunization, esat-6 antigen, receptor, gene, protein, reactivity, infection, vaccination, Adolescence, Antigens, Bacterial, immunology, Child, Diseases in Twins, Female, Gambia, Genetic Predisposition to Disease, Human, Interferon Type II, metabolism, Lymphocyte Transformation, immunology, Male, Mycobacterium tuberculosis, immunology, Skin Tests, Support, Non-U.S. Gov't, T-Lymphocytes, immunology, Tuberculosis, genetics, immunology, Twins|
|Faculty and Department:||Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology|
|Web of Science ID:||168784300060|
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