Dynamics of the antibody response to Plasmodium falciparum infection in African children.

White, MT; Griffin, JT; Akpogheneta, O; Conway, DJ; Koram, KA; Riley, EM; Ghani, AC; (2014) Dynamics of the antibody response to Plasmodium falciparum infection in African children. The Journal of infectious diseases, 210 (7). pp. 1115-22. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiu219

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BACKGROUND: Acquired immune responses to malaria have widely been perceived to be short-lived, with previously immune individuals losing immunity when they move from malaria-endemic areas. However long-lived Plasmodium falciparum-specific antibody responses lasting for an individual's lifetime are frequently observed.<br/> METHODS: We fit mathematical models of the dynamics of antibody titers to P. falciparum antigens from longitudinal cohort studies of African children to estimate the half-lives of circulating immunoglobulin G (IgG) antibodies and IgG antibody-secreting cells (ASCs).<br/> RESULTS: Comparison of antibody responses in the younger Ghanaian cohort and the older Gambian cohort suggests that young children are less able to generate the long-lived ASCs necessary to maintain the circulating antibodies that may provide protection against reinfection. Antibody responses in African children can be described by a model 15 including both short-lived ASCs (half-life range, 2-10 days), which are responsible for boosting antibody titers following infection, and long-lived ASCs (half-life range, 3-9 years), which are responsible for maintaining sustained humoral responses.<br/> CONCLUSIONS: The rapid decay of antibodies following exposure to malaria and the maintenance of sustained antibody responses can be explained in terms of populations of short-lived and long-lived ASCs.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 24719471
Web of Science ID: 344609100016
URI: http://researchonline.lshtm.ac.uk/id/eprint/1649010


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