Antiretroviral therapy abrogates association between arginase activity and HIV disease severity.


Cloke, TE; Abebe, T; Hailu, A; Munder, M; Taylor, GP; Müller, I; Kropf, P; (2010) Antiretroviral therapy abrogates association between arginase activity and HIV disease severity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104 (11). pp. 746-8. ISSN 0035-9203 DOI: https://doi.org/10.1016/j.trstmh.2010.08.004

[img]
Preview
Text - Published Version
License:

Download (731kB) | Preview

Abstract

Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4(+) T cell counts (?350 cells/?l) expressed significantly more arginase compared with 21 patients with high CD4(+) T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4(+) T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naïve patients but not in patients undergoing therapy.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 20843532
Web of Science ID: 284797500009
URI: http://researchonline.lshtm.ac.uk/id/eprint/1644

Statistics


Download activity - last 12 months
Downloads since deposit
163Downloads
293Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item