Increased level of arginase activity correlates with disease severity in HIV-seropositive patients.


Cloke, TE; Garvey, L; Choi, BS; Abebe, T; Hailu, A; Hancock, M; Kadolsky, U; Bangham, CR; Munder, M; Müller, I; Taylor, GP; Kropf, P; (2010) Increased level of arginase activity correlates with disease severity in HIV-seropositive patients. The Journal of infectious diseases, 202 (3). pp. 374-85. ISSN 0022-1899 DOI: https://doi.org/10.1086/653736

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Abstract

Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD4(+) T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD4(+) T cells are not sufficient to fully account for immune dysregulation. Arginase-induced l-arginine deprivation is emerging as a key mechanism for the down-regulation of immune responses. Here, we hypothesized that the level of arginase activity increases with disease severity in HIV-seropositive patients. We determined the levels of arginase activity in peripheral blood mononuclear cells from HIV-seropositive patients and uninfected control participants. Our results show that peripheral blood mononuclear cells from HIV-seropositive patients with low CD4(+) T cell counts expressed statistically significantly higher levels of arginase activity, compared with patients with high CD4(+) T cell counts or uninfected control participants. Furthermore, we found a statistically significant correlation between high level of arginase activity and high viral load in HIV-seropositive patients.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 20575659
Web of Science ID: 279444300007
URI: http://researchonline.lshtm.ac.uk/id/eprint/1643

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