The geographical distribution of variant Creutzfeldt-Jakob disease cases in the UK: what can we learn from it?


Cousens, S; Everington, D; Ward, HJT; Huillard D'Aignaux, J; Will, RG; Smith, PG; (2003) The geographical distribution of variant Creutzfeldt-Jakob disease cases in the UK: what can we learn from it? Statistical methods in medical research, 12 (3). pp. 235-246. ISSN 0962-2802 DOI: 10.1191/0962280203sm332ra

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Abstract

The causative agents of variant Creutzfeldt-Jakob disease (vCJD) and of bovine spongiform encephalopathy (BSE) are currently indistinguishable. However, the route(s) by which humans became infected remain unknown. The path by which humans were infected with the BSE agent might impact on the geographical distribution of cases and we therefore sought evidence of regional variation and local clustering of vCJD cases. With the notable exception of a group of five cases in Leicestershire, the absence of local clustering of vCJD cases is compatible with most human exposure to the vCJD agent arising through routes that result in the risk of infection being similar over wide geographical areas, rather than through small-scale local events. Infection through the consumption of mechanically recovered meat (MRM) contaminated with the BSE agent was a potential route for such widespread exposure. An ecological analysis relating the regional incidence of vCJD to historical dietary data does not provide a clear evidence that humans became infected through consumption of MRM.

Item Type: Article
Keywords: Bovine spongiform encephalopathy, clusters, cjd
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Tropical Epidemiology Group
PubMed ID: 12828244
Web of Science ID: 183151900006
URI: http://researchonline.lshtm.ac.uk/id/eprint/16383

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