Evaluation of adverse effects of vaccines: the case-control approach


Smeeth, L; Rodrigues, LC; Hall, AJ; Fombonne, E; Smith, PG; (2002) Evaluation of adverse effects of vaccines: the case-control approach. Vaccine, 20 (19-20). pp. 2611-7. ISSN 0264-410X DOI: 10.1016/S0264-410X(02)00147-0

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Abstract

When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpretation of case-control studies to evaluate vaccine adverse effects. Potential biases (and how to minimise such biases) in the selection of cases and assessment of vaccine exposure and the potential for confounding are discussed. Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered.

Item Type: Article
Keywords: Case-Control Studies, Confounding Factors (Epidemiology), Human, Support, Non-U.S. Gov't, Vaccines/*adverse effects
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
PubMed ID: 12057620
Web of Science ID: 176456200025
URI: http://researchonline.lshtm.ac.uk/id/eprint/16379

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