Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.


Choi, BS; Martinez-Falero, IC; Corset, C; Munder, M; Modolell, M; Müller, I; Kropf, P; (2009) Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages. Journal of leukocyte biology, 85 (2). pp. 268-77. ISSN 0741-5400 DOI: https://doi.org/10.1189/jlb.0508310

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Abstract

The metabolism of the amino acid L-arginine is emerging as a crucial mechanism for the regulation of immune responses. Here, we characterized the impact of L-arginine deprivation on T cell and macrophage (MPhi) effector functions: We show that whereas L-arginine is required unconditionally for T cell activation, MPhi can up-regulate activation markers and produce cytokines and chemokines in the absence of L-arginine. Furthermore, we show that L-arginine deprivation does not affect the capacity of activated MPhi to up-regulate L-arginine-metabolizing enzymes such as inducible NO synthase and arginase 1. Thus, our results show that to exert their effector functions, T cells and MPhi have different requirements for L-arginine.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 19008294
Web of Science ID: 262891700009
URI: http://researchonline.lshtm.ac.uk/id/eprint/1637

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