Age-related alteration of arginase activity impacts on severity of leishmaniasis.

Müller, I; Hailu, A; Choi, BS; Abebe, T; Fuentes, JM; Munder, M; Modolell, M; Kropf, P; (2008) Age-related alteration of arginase activity impacts on severity of leishmaniasis. PLoS neglected tropical diseases, 2 (5). e235. ISSN 1935-2727 DOI:

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The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality. The clinical outcome of infection with Leishmania parasites depends on a variety of factors such as parasite species, vector-derived products, genetics, behaviour, and nutrition. The age of the infected individuals also appears to be critical, as a significant proportion of clinical cases occur in children; this age-related higher prevalence of disease is most remarkable in visceral leishmaniasis. The mechanisms resulting in this higher incidence of clinical disease in children are poorly understood. We have recently revealed that sustained arginase activity promotes uncontrolled parasite growth and pathology in vivo. Here, we tested the hypothesis that arginase-mediated L-arginine metabolism differs with age.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 18478052
Web of Science ID: 261806900010


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