HIV-1 subtypes and the HIV epidemics in four cities in sub-Saharan Africa


Morison, L; Buve, A; Zekeng, L; Heyndrickx, L; Anagonou, S; Musonda, R; Kahindo, M; Weiss, HA; Hayes, RJ; Laga, M; Janssens, W; van der Groen, G; (2001) HIV-1 subtypes and the HIV epidemics in four cities in sub-Saharan Africa. AIDS (London, England), 15 Suppl 4. S109-16. ISSN 0269-9370

Full text not available from this repository.

Abstract

OBJECTIVE: To describe the distribution of HIV-1 subtypes in two cities with high HIV prevalence (Kisumu, Kenya and Ndola, Zambia) and two with relatively low prevalence (Cotonou, Benin and Yaoundé, Cameroon), and to examine whether the differences in prevalence of HIV infection could be due to the predominance within the infected populations of subtypes with differing efficiency of heterosexual transmission. METHODS: For around 100 randomly selected HIV-positive sera from the general population and 60 from sex workers in each city, the HIV-1 subtype was determined in the envfragment. For between 19 and 52 of the sera from the general population and 20-32 sera from sex workers, the subtype was also determined in the gag fragment. RESULTS: Over 70% of infections in Cotonou, Yaoundé and Kisumu were with subtype A (by env). However, around one-half of subtype A infections in Cotonou and Yaoundé were found to be the circulating recombinant form CRF02_AG when the gag fragment was also examined. A large number of different HIV strains were found in Yaoundé, including some belonging to group O. Over 20% of infections in Kisumu and around 10% in Yaoundé were with isolated intersubtype recombinant forms. All but a few infections in Ndola were with subtype C and no recombinants were found. CONCLUSIONS: The pattern of distribution of subtypes that we found does not suggest that differences in circulating subtypes play a major role in explaining the differences in prevalence of HIV-1 infection between the four cities. The emergence and spread of recombinants requires close surveillance to adapt testing strategies if needed, to inform vaccine development and to ascertain their role in the future spread of HIV.

Item Type: Article
Keywords: Adolescent, Adult, Africa South of the Sahara/epidemiology, *Disease Outbreaks, Female, Gene Products, env/genetics, Gene Products, gag/genetics, HIV Infections/*epidemiology/transmission/virology, HIV-1/*classification/*genetics, Heteroduplex Analysis, Heterosexuality, Human, Male, Prevalence, Prostitution, *Urban Population, Adolescence, Adult, Africa South of the Sahara, epidemiology, Disease Outbreaks, Female, Gene Products, env, genetics, Gene Products, gag, genetics, HIV Infections, epidemiology, transmission, virology, HIV-1, classification, genetics, Heteroduplex Analysis, Heterosexuality, Human, Male, Prevalence, Prostitution, Urban Population
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Tropical Epidemiology Group
PubMed ID: 11686459
Web of Science ID: 171519300012
URI: http://researchonline.lshtm.ac.uk/id/eprint/16331

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
311Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item