Indole and beta-carboline alkaloids from Geissospermum sericeum


Steele, JCP; Veitch, NC; Kite, GC; Simmonds, MSJ; Warhurst, DC; (2002) Indole and beta-carboline alkaloids from Geissospermum sericeum. Journal of natural products, 65 (1). pp. 85-8. ISSN 0163-3864 DOI: https://doi.org/10.1021/np0101705

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Abstract

The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.

Item Type: Article
Keywords: Antimalarial, Animal, Antimalarials, chemistry, isolation & purification, pharmacology, Brazil, Carbolines, chemistry, isolation & purification, pharmacology, Chloroquine, pharmacology, Chromatography, Thin Layer, Drug Resistance, Human, Inhibitory Concentration 50, KB Cells, drug effects, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Bark, chemistry, Plants, Medicinal, chemistry, Plasmodium falciparum, drug effects, Spectrophotometry, Ultraviolet, Support, Non-U.S. Gov't, Tumor Cells, Cultured, drug effects
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 11809075
Web of Science ID: 173618200023
URI: http://researchonline.lshtm.ac.uk/id/eprint/16307

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