Rational use of drugs against Plasmodium falciparum

Warhurst, DC; Duraisingh, MT; (2001) Rational use of drugs against Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene, 95 (4). pp. 345-6. ISSN 0035-9203

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Recent studies on resistance to blood schizontocides in Plasmodium falciparum give a rational basis for the use of artemisinins combined with arylaminoalcohols for the treatment of uncomplicated chloroquine-resistant malaria in Africa. In areas where such combinations are introduced, there is reason to believe that the continued use of chloroquine in the community will help protect the new drugs from resistance. In view of several laboratory studies, combinations of artemisinins with antifolates or chloroquine pose a risk of antagonistic interaction. This can be avoided by use of the artemisinin and the companion drug sequentially.

Item Type: Article
Keywords: Animal, Antimalarials/*standards/*therapeutic use, Chloroquine/therapeutic use, Drug Combinations, Drug Resistance, Human, Malaria, Falciparum/*drug therapy, Plasmodium falciparum/drug effects, Sesquiterpenes/*therapeutic use, Animal, Antimalarials, standards, therapeutic use, Chloroquine, therapeutic use, Drug Combinations, Drug Resistance, Human, Malaria, Falciparum, drug therapy, Plasmodium falciparum, drug effects, Sesquiterpenes, therapeutic use
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Malaria Centre
PubMed ID: 11579870
Web of Science ID: 171336900001
URI: http://researchonline.lshtm.ac.uk/id/eprint/16303


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