Performance by cytology and hybrid capture II in screening for high-grade squamous intraepithelial lesions in women with HIV


Raposo, LM; Velasque, L; Luz, PM; Friedman, RK; Cytryn, A; de Andrade, ACV; Vanni, T; Brasil, P; Russomano, F; Veloso, VG; Grinsztejn, B; Struchiner, CJ; (2011) Performance by cytology and hybrid capture II in screening for high-grade squamous intraepithelial lesions in women with HIV. Cadernos de saude publica, 27 (7). pp. 1281-1291. ISSN 0102-311X

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Abstract

HIV-infected women are at increased risk of developing high-grade squamous intraepithelial lesions (HSIL), the precursor lesions for cervical cancer. This study estimated and compared the performance of cytology and hybrid capture II in screening for precursor lesions of cervical cancer among HIV-infected women. The study population consisted of women from the open prospective cohort at the Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation (IPEC/Fiocruz). Colposcopy and histology were considered jointly in defining the gold standard. Cytology showed 31.8% sensitivity and 95.5% specificity, while hybrid capture II showed higher sensitivity (100%) and lower specificity (52%). The positive likelihood ratio was 7.1 for cytology and 2.1 for hybrid capture II, while the negative likelihood ratio was 0.7 for cytology and 0.0 for hybrid capture II.

Item Type: Article
Keywords: Uterine Cervical Neoplasms, HIV, Women, active antiretroviral therapy, human-papillomavirus infection, human-immunodeficiency-virus, rio-de-janeiro, cervical-cancer, positive, women, metaanalysis, neoplasia, accuracy, cohort
Faculty and Department: Faculty of Public Health and Policy
Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 21808813
Web of Science ID: 293441700004
URI: http://researchonline.lshtm.ac.uk/id/eprint/163

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