Kinetics of delayed-type hypersensitivity to tuberculin induced by bacille Calmette-Guerin vaccination in northern Malawi


Floyd, S; Ponnighaus, JM; Bliss, L; Nkhosa, P; Sichali, L; Msiska, G; Fine, PE; (2002) Kinetics of delayed-type hypersensitivity to tuberculin induced by bacille Calmette-Guerin vaccination in northern Malawi. The Journal of infectious diseases, 186 (6). pp. 807-14. ISSN 0022-1899 DOI: 10.1086/342416

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Abstract

During 1986-1989, a bacille Calmette-Guerin (BCG) vaccine trial was carried out in northern Malawi. The effects of age, sex, and prevaccination delayed-type hypersensitivity (DTH) on the time course of the DTH response over 1-36 months after vaccination were studied in 2418 persons. DTH response increased rapidly, to peak at 31-90 days after vaccination, when most persons had a measurable response. This was followed by a marked decline by 181-365 days, particularly in those <15 years old at vaccination, followed by a more gradual decline. Prevaccination DTH was the single best predictor of postvaccination DTH. BCG-induced DTH responsiveness appears to decline more rapidly in tropical than in temperate environments. This may reflect high prevalence of exposure to other infections, which induce a Th2 bias or compete for "space" within the T lymphocyte compartment. The inability of some persons to mount a persistent DTH response probably reflects genetic background and/or environmental exposure history.

Item Type: Article
Keywords: Adolescent, Adult, Age Factors, BCG Vaccine/*immunology, Child, Child, Preschool, Female, Human, Hypersensitivity, Delayed/epidemiology/*immunology, Kinetics, Logistic Models, Malawi/epidemiology, Male, Middle Age, Support, Non-U.S. Gov't, Time Factors, Tuberculin/*immunology, *Tuberculin Test, Adolescence, Adult, Age Factors, BCG Vaccine, immunology, Child, Child, Preschool, Female, Human, Hypersensitivity, Delayed, epidemiology, immunology, Kinetics, Logistic Models, Malawi, epidemiology, Male, Middle Age, Support, Non-U.S. Gov't, Time Factors, Tuberculin, immunology, Tuberculin Test
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: MEIRU
Population Studies Group
TB Centre
Vaccine Centre
PubMed ID: 12198615
Web of Science ID: 177694800011
URI: http://researchonline.lshtm.ac.uk/id/eprint/16290

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