Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi


Black, GF; Dockrell, HM; Crampin, AC; Floyd, S; Weir, RE; Bliss, L; Sichali, L; Mwaungulu, L; Kanyongoloka, H; Ngwira, B; Warndorff, DK; Fine, PEM; (2001) Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi. The Journal of infectious diseases, 184 (3). pp. 322-329. ISSN 0022-1899 DOI: https://doi.org/10.1086/322042

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Abstract

Interferon (IFN)-gamma responsiveness to 12 purified protein derivative (PPD) and new tuberculin antigens from 9 species of mycobacteria was assessed, using a whole blood assay, in 616 young adults living in northern Malawi, where Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccination provides no protection against pulmonary tuberculosis. The prevalence of IFN-gamma responsiveness was highest for PPDs of M. avium, M. intracellulare, and M. scrofulaceum (the MAIS complex). Correlations between responsiveness paralleled genetic relatedness of the mycobacterial species. A randomized, controlled trial was carried out, to assess the increase in IFN-gamma responsiveness to M. tuberculosis PPD that can be attributed to M. bovis BCG vaccination. The BCG-attributable increase in IFN-gamma response to M. tuberculosis PPD was greater for individuals with low initial responsiveness to MAIS antigens than for those with high initial responsiveness. Although not statistically significant, the trend is consistent with the hypothesis that prior exposure to environmental mycobacteria interferes with immune responses to BCG vaccination.

Item Type: Article
Keywords: Whole-blood assay, t-cell responses, interferon-gamma, leprosy, patients, bcg vaccination, heterologous immunity, protective, immunity, healthy-subjects, bovis bcg, infection, Antigens, Bacterial, immunology, Cross Reactions, Human, Immunity, Natural, Interferon Type II, biosynthesis, blood, Malawi, Mycobacteria, Atypical, classification, immunology, Mycobacterium, classification, immunology, Mycobacterium Infections, immunology, Mycobacterium avium, classification, immunology, Mycobacterium avium Complex, classification, immunology, Mycobacterium bovis, classification, immunology, Skin Tests, Statistics, Nonparametric, Support, Non-U.S. Gov't, Tuberculin Test, Tuberculosis, epidemiology, Tuberculosis, Pulmonary, epidemiology, immunology
Faculty and Department: Academic Services & Administration > Academic Administration
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
MEIRU
Population Studies Group
PubMed ID: 11443558
Web of Science ID: 169961600010
URI: http://researchonline.lshtm.ac.uk/id/eprint/16278

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