Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections


Albonico, M; Bickle, Q; Haji, HJ; Ramsan, M; Khatib, KJ; Montresor, A; Savioli, L; Taylor, M; (2002) Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 (6). pp. 685-90. ISSN 0035-9203 DOI: https://doi.org/10.1016/S0035-9203(02)90352-4

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Abstract

A randomized controlled trial comparing the efficacy of pyrantel-oxantel (10 mg/kg) with mebendazole (500 mg) was performed on 1329 schoolchildren aged 6-9 years on Pemba Island in September-October 2000 to evaluate alternative single-dose drugs for regular treatment of intestinal nematode infections. Both mebendazole and pyrantel-oxantel were very effective in eliminating Ascaris lumbricoides infection, inducing cure rates of more than 96% and reducing the mean egg counts by more than 95%. Both drugs had a moderate efficacy against Trichuris trichiura infection, but pyrantel-oxantel had a higher cure rate (31.5% vs. 23.3%, P < 0.01), though the reductions in egg counts did not differ significantly and were more than 80%. Pyrantel-oxantel and mebendazole had a similar, poor efficacy in curing hookworm infections and had a moderate effect in reducing the egg counts by 67% and 68%, respectively. Pyrantel-oxantel (10 mg/kg) offers a valuable alternative to mebendazole as a single-dose treatment for the control of intestinal nematode infections in children in endemic areas of sub-Saharan Africa, due to its comparable efficacy, its low cost and its suitability for use in young children.

Item Type: Article
Keywords: helminths, Ascaris lumbricoides, Trichuris trichiura, hookworm, control, chemotherapy, pyrantel-oxantel, mebendazole, Pemba, Island, Albendazole, mebendazole, ivermectin, children, trial, Antinematodal Agents, therapeutic use, Ascariasis, drug therapy, Child, Hookworm Infections, drug therapy, Human, Intestinal Diseases, Parasitic, drug therapy, Nematode Infections, drug therapy, Pyrantel, analogs & derivatives, therapeutic use, Soil, parasitology, Support, Non-U.S. Gov't, Treatment Outcome, Trichuriasis, drug therapy
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 12625151
Web of Science ID: 181165200027
URI: http://researchonline.lshtm.ac.uk/id/eprint/16269

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