Both Interleukin-4 (IL-4) and IL-4 Receptor alpha Signaling Contribute to the Development of Hepatic Granulomas with Optimal Antileishmanial Activity


Stager, S; Alexander, J; Carter, KC; Brombacher, F; Kaye, PM; (2003) Both Interleukin-4 (IL-4) and IL-4 Receptor alpha Signaling Contribute to the Development of Hepatic Granulomas with Optimal Antileishmanial Activity. Infection and immunity, 71. pp. 4804-4807. ISSN 0019-9567 DOI: https://doi.org/10.1128/iai.71.8.4804-4807.2003

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Abstract

The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice correlates with increased NOS2 expression and decreased serum gamma interferon levels. IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 12874364
Web of Science ID: 184392700068
URI: http://researchonline.lshtm.ac.uk/id/eprint/16207

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