Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis


de Souza, JB; Riley, EM; (2002) Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis. Microbes and infection / Institut Pasteur, 4 (3). pp. 291-300. ISSN 1286-4579

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Abstract

: Cerebral malaria is a serious and often fatal complication of Plasmodium falciparum infections. The precise mechanisms involved in the onset of neuropathology remain unknown, but parasite sequestration in the brain, metabolic disturbances and host immune responses are all thought to be involved. This review outlines the current state of knowledge of cerebral disease in humans, and discusses the contribution of studies of animal models to elucidation of the underlying mechanisms.<br/>

Item Type: Article
Keywords: Animal, *Disease Models, Animal, Haplorhini, Human, Interleukins/biosynthesis, Malaria, Cerebral/*immunology/parasitology/pathology, Mice, Plasmodium falciparum/growth & development/pathogenicity, Support, Non-U.S. Gov't, T-Lymphocytes/immunology, Tumor Necrosis Factor/biosynthesis, Animal, Disease Models, Animal, Haplorhini, Human, Interleukins, biosynthesis, Malaria, Cerebral, immunology, parasitology, pathology, Mice, Plasmodium falciparum, growth & development, pathogenicity, Support, Non-U.S. Gov't, T-Lymphocytes, immunology, Tumor Necrosis Factor, biosynthesis
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 11909739
URI: http://researchonline.lshtm.ac.uk/id/eprint/16196

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