Outbreak of aseptic meningitis and mumps after mass vaccination with MMR vaccine using the Leningrad-Zagreb mumps strain


da Cunha, SS; Rodrigues, LC; Barreto, ML; Dourado, I; (2002) Outbreak of aseptic meningitis and mumps after mass vaccination with MMR vaccine using the Leningrad-Zagreb mumps strain. Vaccine, 20 (7-8). pp. 1106-12. ISSN 0264-410X DOI: 10.1016/S0264-410X(01)00438-8

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Abstract

Data from routine surveillance during two mass immunisation campaigns (MIC) with Measles-mumps-rubella (MMR)vaccine using Leningrad-Zagreb mumps strain in two states in Brazil were analysed to estimate the risk of vaccine-related meningitis and mumps. Increase in the incidence of the two diseases was observed in both states, 3 weeks after the vaccination campaigns. The estimated number of doses applied per one case of vaccine-related meningitis ranged from 6199 (95% CI: 4854-8058) to 19,247 (95% CI: 12,648-29,513) depending on the diagnostic criteria used and state. It was 300 doses (95% CI: 286-317) for each case of mumps. The implications for vaccination policy are discussed.

Item Type: Article
Keywords: Child, Child, Preschool, *Disease Outbreaks, Human, Infant, Measles-Mumps-Rubella Vaccine/*adverse effects, Meningitis, Aseptic/*epidemiology, Mumps/*epidemiology, Support, Non-U.S. Gov't, Vaccination/*adverse effects, Child, Child, Preschool, Disease Outbreaks, Human, Infant, Measles-Mumps-Rubella Vaccine, adverse effects, Meningitis, Aseptic, epidemiology, Mumps, epidemiology, Support, Non-U.S. Gov't, Vaccination, adverse effects
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
PubMed ID: 11803071
Web of Science ID: 173858200017
URI: http://researchonline.lshtm.ac.uk/id/eprint/16193

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