Rapid selection of chemokine receptor gene variants by HIV in Africa? (Brief Communication)

Ramaley, PA; French, N; Kaleebu, P; Gilks, CF; Whitworth, JAG; Hill, AVS; (2002) Rapid selection of chemokine receptor gene variants by HIV in Africa? (Brief Communication). Nature, 417 (6885). p. 140. ISSN 0028-0836 DOI: https://doi.org/10.1038/417140a

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Schliekelman et al. have provided a model to quantify the speed at which HIV-resistance haplotypes can become enriched in a susceptible population through a delay in the onset of AIDS, permitting greater lifetime reproduction and the selection of AIDS-delaying haplotypes. But we question their conclusion that there could be a rapid evolution of resistance to AIDS onset in some African populations if the current HIV epidemic persists, as this depends on an untested assumption: that variant forms of the chemokine-receptor-5 (CCR5) gene impart selective advantages or disadvantages in Africa that are comparable to those reported for African Americans. Here we test this premise in a large Ugandan population, and find that CCR5 variants are not associated with HIV/AIDS disease risk in Africa--the origin and centre of the current AIDS pandemic. This gene may therefore not be subject to rapid evolutionary change as a result of the HIV epidemic in Africa.

Item Type: Article
Keywords: Acquired Immunodeficiency Syndrome, epidemiology, genetics, virology, Alleles, Caucasoid Race, genetics, Disease Progression, Evolution, Molecular, Gene Frequency, Genetic Predisposition to Disease, genetics, HIV-1, classification, isolation & purification, Haplotypes, genetics, Human, Linkage Disequilibrium, genetics, Models, Genetic, Negroid Race, genetics, Promoter Regions (Genetics), genetics, Receptors, CCR5, genetics, Receptors, Chemokine, genetics, Regression Analysis, Selection (Genetics), Uganda, epidemiology, Variation (Genetics), genetics
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 12000952
Web of Science ID: 175460200033
URI: http://researchonline.lshtm.ac.uk/id/eprint/16093


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