Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s

McCormack, GP; Glynn, JR; Crampin, AC; Sibande, F; Mulawa, D; Fine, PEM; Clewley, JP; (2003) Highly divergent HIV type 1 group M sequences evident in Karonga District, Malawi in the early 1980s. AIDS research and human retroviruses, 19 (5). pp. 441-445. ISSN 0889-2229 DOI: https://doi.org/10.1089/088922203765551782

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Six divergent HIV-1 partial env and gag genome sequences have been characterized in five subjects in Malawi, from whom blood spot samples were collected between 1982 and 1989, at the time that the AIDS epidemic there was starting. These sequences could not be classified with any of the recognized subtypes or circulating recombinant forms of HIV-1. They showed no consistent and/or supported associations with other subtypes by either env or gag gene phylogenetic analysis. Their genetic distances from defined subtypes suggest that they may be diverse subsubtype C viruses or, alternatively, that they may have mosaic genomes. Bootscanning analyses are consistent with their being mosaic viruses. These sequences highlight early HIV-1 diversity in a population otherwise dominated by subtype C.

Item Type: Article
Keywords: epidemic, recombination, evolution, africa, congo, Genes, env, genetics, Genes, gag, genetics, HIV Infections, epidemiology, virology, HIV-1, classification, genetics, Human, Malawi, epidemiology, Molecular Sequence Data, Sequence Analysis, DNA, Support, Non-U.S. Gov't, Variation (Genetics)
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: MEIRU
PubMed ID: 12816092
Web of Science ID: 183234800010
URI: http://researchonline.lshtm.ac.uk/id/eprint/16070


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