Dissection of the genetics of Parkinson's disease identifies an additional association 5 ' of SNCA and multiple associated haplotypes at 17q21


Spencer, CCA; Plagnol, V; Strange, A; Gardner, M; Paisan-Ruiz, C; Band, G; Barker, RA; Bellenguez, C; Bhatia, K; Blackburn, H; Blackwell, JM; Bramon, E; Brown, MA; Burn, D; Casas, JP; Chinnery, PF; Clarke, CE; Corvin, A; Craddock, N; Deloukas, P; Edkins, S; Evans, J; Freeman, C; Gray, E; Hardy, J; Hudson, G; Hunt, S; Jankowski, J; Langford, C; Lees, AJ; Markus, HS; Mathew, CG; McCarthy, MI; Morrison, KE; Palmer, CNA; Pearson, JP; Peltonen, L; Pirinen, M; Plomin, R; Potter, S; Rautanen, A; Sawcer, SJ; Su, Z; Trembath, RC; Viswanathan, AC; Williams, NW; Morris, HR; Donnelly, P; Wood, NW; (2011) Dissection of the genetics of Parkinson's disease identifies an additional association 5 ' of SNCA and multiple associated haplotypes at 17q21. Human molecular genetics, 20 (2). pp. 345-353. ISSN 0964-6906 DOI: https://doi.org/10.1093/hmg/ddq469

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Abstract

We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 French PD cases and 1984 controls for the 27 regions showing the strongest evidence of association (P < 10(-4)). We replicated published associations in the 4q22/SNCA and 17q21/MAPT chromosome regions (P < 10(-10)) and found evidence for an additional independent association in 4q22/SNCA. A detailed analysis of the haplotype structure at 17q21 showed that there are three separate risk groups within this region. We found weak but consistent evidence of association for common variants located in three previously published associated regions (4p15/BST1, 4p16/GAK and 1q32/PARK16). We found no support for the previously reported SNP association in 12q12/LRRK2. We also found an association of the two SNPs in 4q22/SNCA with the age of onset of the disease.

Item Type: Article
Keywords: GENOME-WIDE ASSOCIATION, PROGRESSIVE SUPRANUCLEAR PALSY, RISK-FACTORS, TAU, REGION, INVERSION
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: The International Centre for Evidence in Disability
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 21044948
Web of Science ID: 285626900013
URI: http://researchonline.lshtm.ac.uk/id/eprint/1607

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