Genes to genetic immunization: identification of bacterial vaccine candidates


Allan, E; Wren, BW; (2003) Genes to genetic immunization: identification of bacterial vaccine candidates. Methods (San Diego, Calif), 31 (3). pp. 193-198. ISSN 1046-2023 DOI: https://doi.org/10.1016/s1046-2023(03)00133-6

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Abstract

Pathogenic bacteria still represent a major threat to human health worldwide and the need for new vaccines is great. Virulence factors, particularly surface-located molecules, often make good vaccine targets because they are essential for access to their niche within the host. The advent of whole- genome sequencing of bacterial pathogens has revolutionized the methods by which these organisms are studied and provides us with the possibility of identifying potential targets for vaccines by sequence scanning alone. Other developments in molecular biology, such as whole genome expression and mass mutagenesis, are also contributing to the identification of potential vaccine targets. In this chapter, we review approaches that exploit whole genome sequence data to identify potential virulence determinants and vaccine antigens. (C) 2003 Elsevier Science (USA). All rights reserved.

Item Type: Article
Keywords: pathogen, bacteria, genome, proteome, infectious disease, tagged transposon mutagenesis, complete genome sequence, pathogen helicobacter-pylori, campylobacter-jejuni, virulence, genes, mycobacterium-tuberculosis, neisseria-meningitidis, streptococcus-pneumoniae, staphylococcus-aureus, chlamydia-, trachomatis
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 14511951
Web of Science ID: 185728200003
URI: http://researchonline.lshtm.ac.uk/id/eprint/15959

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