CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population.


Mirghani, RA; Sayi, J; Aklillu, E; Allqvist, A; Jande, M; Wennerholm, A; Eriksen, J; Herben, VM; Jones, BC; Gustafsson, LL; Bertilsson, L; (2006) CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population. Pharmacogenetics and genomics, 16 (9). pp. 637-45. ISSN 1744-6872 DOI: https://doi.org/10.1097/01.fpc.0000230411.89973.1b

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Abstract

To study the correlation between CYP3A5 genotype and quinine 3-hydroxylation in black Tanzanian and Swedish Caucasians as well as to investigate the interethnic differences in CYP3A activity between the two populations.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 16906018
Web of Science ID: 240584800003
URI: http://researchonline.lshtm.ac.uk/id/eprint/1592

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