Seroepidemiological study of herpes simplex virus types 1 and 2 in Brazil, Estonia, India, Morocco, and Sri Lanka


Cowan, FM; French, RS; Mayaud, P; Gopal, R; Robinson, NJ; de Oliveira, SA; Faillace, T; Uuskula, A; Nygard-Kibur, M; Ramalingam, S; Sridharan, G; el Aouad, R; Alami, K; Rbai, M; Sunil-Chandra, NP; Brown, DW; (2003) Seroepidemiological study of herpes simplex virus types 1 and 2 in Brazil, Estonia, India, Morocco, and Sri Lanka. Sexually transmitted infections, 79 (4). pp. 286-290. ISSN 1368-4973 DOI: 10.1136/sti.79.4.286

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Abstract

Background: The association between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) and the development of HSV vaccines have increased interest in the study of HSV epidemiology. Objectives: To estimate the age and sex specific seroprevalence of HSV-1 and HSV-2 infections in selected populations in Brazil, Estonia, India, Morocco, and Sri Lanka. Methods: Serum samples were collected from various populations including children, antenatal clinic attenders, blood donors, hospital inpatients, and HIV sentinel surveillance groups. STD clinic attenders were enrolled in Sri Lanka, male military personnel in Morocco. Sera were tested using a common algorithm by type specific HSV-1 and HSV-2 antibody assay. Results: 13 986 samples were tested, 45.0% from adult females, 32.7% from adult males, and 22.3% from children. The prevalence of HSV-1 varied by site ranging from 78.5%-93.6% in adult males and from 75.5%-97.8% in adult females. In all countries HSV-1 seroprevalence increased significantly with age (p<0.001) in both men and women. The prevalence of HSV-2 infection varied between sites. Brazil had the highest age specific rates of infection for both men and women, followed by Sri Lanka for men and Estonia for women, the lowest rates being found in Estonia for men and India for women. In all countries, HSV-2 seroprevalence increased significantly with age (p<0.01) and adult females had higher rates of infection than adult males by age of infection. Conclusions: HSV-1 and HSV-2 seroprevalence was consistently higher in women than men, particularly for HSV-2. Population based data on HSV-1 and HSV- 2 will be useful for designing potential HSV-2 vaccination strategies and for focusing prevention efforts for HSV-1 and HSV-2 infection.

Item Type: Article
Keywords: Genital herpes, infection, antibody, epidemiology, acquisition, health, marker, hsv-2, risk, Adolescent, Adult, Brazil, epidemiology, Child, Child, Preschool, Estonia, epidemiology, Female, Herpes Simplex, epidemiology, Herpesvirus 1, Human, immunology, Herpesvirus 2, Human, immunology, Human, India, epidemiology, Infant, Infant, Newborn, Male, Morocco, epidemiology, Odds Ratio, Prevalence, Seroepidemiologic Studies, Sri Lanka, epidemiology, Support, Non-U.S. Gov't
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 12902576
Web of Science ID: 184566000005
URI: http://researchonline.lshtm.ac.uk/id/eprint/15892

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