Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira


Ramirez, I; Carabot, A; Melendez, P; Carmona, J; Jimenez, M; Patel, AV; Crabb, TA; Blunden, G; Cary, PD; Croft, SL; Costa, M; (2003) Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira. Phytochemistry, 64 (2). pp. 645-647. ISSN 0031-9422 DOI: https://doi.org/10.1016/s0031-9422(03)00241-3

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Abstract

From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2- hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line. (C) 2003 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Cissampelos pareira, Menispermaceae, phytochemistry, chalcone-, flavone dimer, cissampeloflavone, antiprotozoal, antitrypanosomal
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 12943789
Web of Science ID: 185421800039
URI: http://researchonline.lshtm.ac.uk/id/eprint/15835

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