Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira.

Irama Ramírez ; Alfredo Carabot ; Pablo Meléndez ; Juan Carmona ; Manuel Jimenez ; Asmita V Patel ; Trevor A Crabb ; Gerald Blunden ; Peter D Cary ; Simon L Croft ORCID logo ; +1 more... Manuel Costa ; (2003) Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira. Phytochemistry, 64 (2). pp. 645-647. ISSN 0031-9422 DOI: 10.1016/s0031-9422(03)00241-3
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From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.

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