Discrimination of single band IS6110 DNA fingerprints of Mycobacterium tuberculosis isolates using high-resolution minisatellite-based typing.


Lee, ASG; Tang, LLH; Lim, IHK; Bellamy, R; Wong, S.-, Y; (2002) Discrimination of single band IS6110 DNA fingerprints of Mycobacterium tuberculosis isolates using high-resolution minisatellite-based typing. Journal of clinical microbiology, 40 (2). pp. 657-9. ISSN 0095-1137 DOI: https://doi.org/10.1128/JCM.40.2.657-659.2002

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Abstract

Seven isoniazid-resistant isolates with mutations in the NADH dehydrogenase (ndh) gene were molecularly typed by IS6110-based restriction fragment length polymorphism analysis. All seven isolates with the R268H mutation had identical 1.4-kb IS6110 fingerprints. High-resolution minisatellite-based typing discriminated five of these isolates; two isolates were identical.

Item Type: Article
Keywords: Bacterial Typing Techniques, DNA Fingerprinting, methods, DNA Transposable Elements, Human, Minisatellite Repeats, genetics, Mycobacterium tuberculosis, classification, genetics, isolation & purification, Polymorphism, Restriction Fragment Length, Support, Non-U.S. Gov't, Tuberculosis, Pulmonary, microbiology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 11825989
Web of Science ID: 173731900054
URI: http://researchonline.lshtm.ac.uk/id/eprint/15685

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