The effect of distance on observed mortality, childhood pneumonia and vaccine efficacy in rural Gambia.


Zaman, SM; Cox, J; Enwere, GC; Bottomley, C; Greenwood, BM; Cutts, FT; (2014) The effect of distance on observed mortality, childhood pneumonia and vaccine efficacy in rural Gambia. Epidemiology and infection, 142 (12). pp. 2491-500. ISSN 0950-2688 DOI: 10.1017/S0950268814000314

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Abstract

: We investigated whether straight-line distance from residential compounds to healthcare facilities influenced mortality, the incidence of pneumonia and vaccine efficacy against pneumonia in rural Gambia. Clinical surveillance for pneumonia was conducted on 6938 children living in the catchment areas of the two largest healthcare facilities. Deaths were monitored by three-monthly home visits. Children living >5 km from the two largest healthcare facilities had a 2·78 [95% confidence interval (CI) 1·74-4·43] times higher risk of all-cause mortality compared to children living within 2 km of these facilities. The observed rate of clinical and radiological pneumonia was lower in children living >5 km from these facilities compared to those living within 2 km [rate ratios 0·65 (95% CI 0·57-0·73) and 0·74 (95% CI 0·55-0·98), respectively]. There was no association between distance and estimated pneumococcal vaccine efficacy. Geographical access to healthcare services is an important determinant of survival and pneumonia in children in rural Gambia.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Tropical Epidemiology Group
PubMed ID: 24565180
Web of Science ID: 344920800004
URI: http://researchonline.lshtm.ac.uk/id/eprint/1567835

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