Effects of alcohol consumption on the risk of colorectal cancer among men by anatomical subsite (Canada)


Sharpe, CR; Siemiatycki, J; Rachet, B; (2002) Effects of alcohol consumption on the risk of colorectal cancer among men by anatomical subsite (Canada). Cancer causes & control, 13 (5). pp. 483-91. ISSN 0957-5243 DOI: https://doi.org/10.1023/A:1015700415808

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Abstract

OBJECTIVE: To estimate the effects of alcohol consumption on the risk of colorectal cancer according to anatomical subsite. METHODS: Between 1979 and 1985 a population-based case-control study of cancer at multiple sites was carried out in Montreal. This analysis was restricted to the 585 cases with adenocarcinoma of the large bowel, aged 35-70 years, who underwent face-to-face interviews. Controls (n = 500) were selected either from electoral lists or by random-digit dialing and were frequency-matched to the cases on age. Polytomous logistic regression was used to estimate the risk of cancer of the proximal colon, distal colon, and rectum in relation to the consumption of alcoholic beverages. RESULTS: Daily consumption of alcohol of any type was associated with increased risks of cancer of the distal colon [odds ratio (OR)= 2.3; 95% confidence interval (CI) 1.4-3.7] and the rectum (OR = 1.6; 95% Cl 1.0-2.6), but not with an increased risk of cancer of the proximal colon (OR = 1.0; 95% CI: 0.6-1.7). When type of beverage was considered, beer showed strong associations with cancer at all three subsites (ORs among the heaviest drinkers ranging from 1.8 to 2.4), spirits showed weaker associations with cancer at all three subsites (ORs ranging from 1.4 to 1.6), and wine showed null associations. CONCLUSIONS: The results are consistent with the hypothesis that consumption of alcoholic beverages increases the risk of colorectal cancer. The evidence is strongest for effects on the distal colon and rectum, and, among the three types of beverage, it most strongly implicates beer.

Item Type: Article
Keywords: Adult, Aged, Alcohol Drinking/*adverse effects, Beer/*adverse effects, Canada/epidemiology, Case-Control Studies, Colon/*pathology, Colorectal Neoplasms/epidemiology/*etiology/pathology, Human, Incidence, Male, Middle Aged, Rectum/*pathology, Regression Analysis, Support, Non-U.S. Gov't, Adult, Aged, Alcohol Drinking, adverse effects, Beer, adverse effects, Canada, epidemiology, Case-Control Studies, Colon, pathology, Colorectal Neoplasms, epidemiology, etiology, pathology, Human, Incidence, Male, Middle Aged, Rectum, pathology, Regression Analysis, Support, Non-U.S. Gov't
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Cancer Survival Group
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 12146853
Web of Science ID: 175947900011
URI: http://researchonline.lshtm.ac.uk/id/eprint/15611

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