Dementia diagnosis in developing countries: a cross-cultural validation study


Prince, M; Acosta, D; Chiu, H; Scazufca, M; Varghese, M; 10/66 Dementia Research Group (including Patel, V.), ; (2003) Dementia diagnosis in developing countries: a cross-cultural validation study. Lancet, 361 (9361). pp. 909-17. ISSN 0140-6736 DOI: https://doi.org/10.1016/S0140-6736(03)12772-9

Full text not available from this repository. (Request a copy)

Abstract

BACKGROUND: Research into dementia is needed in developing countries. Assessment of variations in disease frequency between regions might enhance our understanding of the disease, but methodological difficulties need to be addressed. We aimed to develop and test a culturally and educationally unbiased diagnostic instrument for dementia. METHODS: In a multicentre study, the 10/66 Dementia Research Group interviewed 2885 people aged 60 years and older in 25 centres, most in Universities, in India, China and southeast Asia, Latin America and the Caribbean, and Africa. 729 had dementia and three groups were free of dementia: 702 had depression, 694 had high education (as defined by each centre), and 760 had low education (as defined by each centre). Local clinicians diagnosed dementia and depression. An interviewer, masked to dementia diagnosis, administered the geriatric mental state, the community screening instrument for dementia, and the modified Consortium to Establish a Registry of Alzheimer's Disease (CERAD) ten-word list-learning task. FINDINGS: Each measure independently predicted a diagnosis of dementia. In an analysis of half the sample, an algorithm derived from all three measures gave better results than any individual measure. Applied to the other half of the sample, this algorithm identified 94% of dementia cases with false-positive rates of 15%, 3%, and 6% in the depression, high education, and low education groups, respectively. INTERPRETATION: Our algorithm is a sound basis for culturally and educationally sensitive dementia diagnosis in clinical and population-based research, supported by translations of its constituent measures into most languages used in the developing world.

Item Type: Article
Keywords: Algorithms, *Cross-Cultural Comparison, Dementia/classification/*diagnosis/epidemiology, Depression/diagnosis/epidemiology, *Developing Countries, *Educational Status, Human, Mental Recall, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Support, Non-U.S. Gov't, Algorithms, Cross-Cultural Comparison, Dementia, classification, diagnosis, epidemiology, Depression, diagnosis, epidemiology, Developing Countries, Educational Status, Human, Mental Recall, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Support, Non-U.S. Gov't
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 12648969
Web of Science ID: 181741600008
URI: http://researchonline.lshtm.ac.uk/id/eprint/15488

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
331Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item