Tracing the dawn of Plasmodium falciparum with mitochondrial genome sequences

Conway, DJ; (2003) Tracing the dawn of Plasmodium falciparum with mitochondrial genome sequences. Trends in genetics, 19 (12). pp. 671-4. ISSN 0168-9525 DOI:

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Until recently, little light had been shed on the murky origins of human malaria. Did Plasmodium falciparum, the most virulent malaria parasite, emerge as a common pathogen only in the past few thousand years, as suggested by some analyses of its nucleotide sequence diversity? Or, was it an ancient scourge of early humans >100000 years ago, as suggested by others? A recent study, using complete mitochondrial DNA sequence polymorphism data and new analytical methods, points to an intermediate date of origin and expansion out of Africa. Subsequent population growth in each continent is less well resolved.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 14642743
Web of Science ID: 187223200002


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