Ethnic differences in the relationship between fasting leptin and BMI in children


Moore, SE; Falorni, A; Bini, V; Fulford, T; O'Connell, MA; Prentice, AM; (2004) Ethnic differences in the relationship between fasting leptin and BMI in children. International journal of obesity and related metabolic disorders, 28 (1). pp. 17-21. ISSN 0307-0565 DOI: https://doi.org/10.1038/sj.ijo.0802484

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Abstract

OBJECTIVE:: To compare the relationship between fasting serum leptin levels and body mass index (BMI) in children from different ethnic groups. SUBJECTS:: Children aged 6-10 y from rural Gambia (n=471) and central Italy (n=839). MEASUREMENTS:: Anthropometry (z-score of BMI) and fasting serum leptin concentrations. RESULTS:: The Italian children had significantly higher mean BMI z-scores than the Gambian children (males: Italy 1.58, Gambia -1.44, P</=0.0001; females: Italy 1.33, Gambia -1.42, P</=0.0001) and significantly higher serum leptin concentrations (males: Italy 8.86 ng ml(-1), Gambia 1.78 ng ml(-1), P</=0.0001; females: Italy 11.31 ng ml(-1), Gambia 2.22 ng ml(-1), P</=0.0001). A significantly different relationship was observed between z-score of BMI and serum leptin levels in the Gambian and the Italian children for both boys and girls. CONCLUSION:: A different relationship exists between z-score of BMI and leptin levels in these two groups of children from very diverse ethnic backgrounds. Future studies using detailed measures of body composition and energy balance are needed to help understand this relationship.International Journal of Obesity (2004) 28, 17-21. doi:10.1038/sj.ijo.0802484 Published online 2 December 2003

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 14652620
Web of Science ID: 187849200004
URI: http://researchonline.lshtm.ac.uk/id/eprint/15164

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